To Observe Whether Isoflurane Can Treat COVID-19 Patients

Completed

Conditions studied: COVID-19

In brief

This is a blood collection and retrospective data collection study. The investigators plan to assess whether the sedative drug, isoflurane, can treat COVID-19 patients relatively better compared to other sedative drugs given during routine treatment to patients on mechanical ventilation. The investigators will also use nanoneedle biosensors to quickly detect blood IgM/IgG ratio in those patients, and (3) to establish a pre-clinical system to determine the effects of inhalational anesthetics on amounts of SARS-CoV-2 and other viruses, and pneumoniae.

Key facts

Study ID

NCT04492943

Run by

Massachusetts General Hospital

People needed

35

Starts

2020-04-20

Expected to finish

2020-06-30

Last updated by the study team

2020-09-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Over the age of 18 years old
• Tested positive for COVID-19
• Documented SARS-CoV-2 carriage in the nasopharyngeal sample by PCR
• Intubated for mechanical ventilation with an anesthesia machine

You may not qualify if…

• Patient or any their family members have any contraindication for inhalation anesthetics (e.g., malignant hyperthermia).

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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