A Smart Approach to Treating Tobacco Use Disorder in Persons Living With HIV

Completed · Phase 4

Conditions studied: Tobacco Use Cessation

In brief

Many people living with HIV (PLWH) smoke. Smoking in these individuals is often undertreated. This study plans to assess the ability of various clinical pathways involving tobacco treatment medications and contingency management (paying smokers for not smoking) to improve smoking cessation in a group of PLWH.

Key facts

Study ID

NCT04490057

Run by

Yale University

People needed

323

Starts

2020-07-27

Expected to finish

2025-10-24

Last updated by the study team

2026-01-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• HIV positive;
• >= 18 years old
• Receiving HIV care at Yale-New Haven Hospital, Bridgeport Hospital, Mount Sinai Hospital, or SUNY Downstate STAR clinic;
• Have smoked >= 100 cigarettes in lifetime;
• Currently smokes some days or every day;
• Smokes, on average, >= 5 cigarettes per day;
• Able to provide written informed consent.

You may not qualify if…

• Using only non-cigarette nicotine products (i.e., e-cigs, Juul, etc.);
• Currently using NRT, VAR, or bupropion (defined as use in the prior 7 days);
• Self-report or urine testing confirming pregnancy, nursing, or trying to conceive;
• Life-threatening or unstable medical, surgical, or psychiatric condition;
• Inability to provide at least one collateral contact (family member or friend);
• Living out of state;
• Unable to read or understand English (except at Mount Sinai site).

Where it is running

• Bridgeport Hospital Infectious Disease Clinic — Bridgeport, Connecticut, United States
• Yale University School of Medicine — New Haven, Connecticut, United States
• SUNY Downstate STAR Clinic — Brooklyn, New York, United States
• Icahn School of Medicine at Mount Sinai — New York, New York, United States

Full record on ClinicalTrials.gov

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