Neurobiological Mechanisms of Stress in Youth With Chronic Widespread Pain
Running, not enrolling · Not applicable
Conditions studied: Chronic Widespread Pain, Stress, Psychological, Stress, Physiological
In brief
Chronic widespread pain (CWP) is a common chronic pain condition in youth and often associated with significant pain-related and psychosocial impairment. Understanding the neurobiological mechanisms that may underlie pediatric chronic pain and pain-related impairment can inform future treatments to ameliorate patients' suffering, making it a critical area of empirical investigation.
Key facts
- Study ID
- NCT04488757
- Run by
- Boston Children's Hospital
- People needed
- 70
- Starts
- 2021-11-04
- Expected to finish
- 2026-08-31
- Last updated by the study team
- 2026-05-22
Who can join
Age: 11 and older, up to 17. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Between ages 11-17 years
- Referred to the Boston Children's Hospital Pain Treatment Service for evaluation of a CWP condition with duration > 3 months
- Right-handed
You may not qualify if…
- Inability to speak sufficient English to complete questionnaires
- Severe cognitive impairment
- Prescription steroidal (interference with cortisol measures) or psychotropic medication
- Any other chronic pain diagnosis (e.g., migraines, abdominal pain, CRPS)
- fMRI contraindications (e.g., dental appliances)
- Healthy Control (HC) group:
- Inclusion Criteria:
- Between ages 11-17 years
- Right-handed
- Exclusion Criteria:
- Inability to speak sufficient English to complete questionnaires
- Severe cognitive impairment
- Prescription steroidal (interference with cortisol measures) or psychotropic medication
- Any chronic pain diagnosis
- Presence of documented chronic (> 3 months) medical condition with an identifiable, organic cause (e.g., diabetes, cystic fibrosis)
- fMRI contraindications (e.g., dental appliances)
Where it is running
- Boston Children's Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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