Long-term Follow-up Study for Patients Treated With CLBR001 CAR-T

Completed · Phase 1

Conditions studied: Relapsed/Refractory B-cell Lymphomas, Diffuse Large B-Cell Lymphoma (DLBCL), Follicular Lymphoma (FL), Chronic Lymphocytic Leukemia (CLL), Marginal Zone Lymphoma (MZL), Mantle Cell Lymphoma (MCL), Small Lymphocytic Lymphoma (SLL), Primary Mediastinal Large B Cell Lymphoma, Transformed Follicular Lymphoma, Waldenstrom Macroglobulinemia, Lymphoplasmacytic Lymphoma, Burkitt Lymphoma

In brief

This study is designed as a long-term follow-up study of participants who have receive genetically modified autologous CLBR001 CAR-T cells

Key facts

Study ID

NCT04488354

Run by

Calibr, a division of Scripps Research

People needed

16

Starts

2021-01-21

Expected to finish

2025-10-06

Last updated by the study team

2026-04-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All patients who received at least one CLBR001 cell dose and have either discontinued early or completed the core treatment protocol or any protocol such as a managed access protocol as applicable.
• Subject is willing and able to adhere to the study visit schedule and other protocol requirements.
• Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol

You may not qualify if…

• There are no specific exclusion criteria for this study

Where it is running

• City of Hope National Medical Center — Duarte, California, United States
• University of California at San Diego — San Diego, California, United States
• University of Chicago — Chicago, Illinois, United States
• Masonic Cancer Center, University of Minnesota — Minneapolis, Minnesota, United States
• Weill Cornell Medical College - New York Presbyterian Hospital — New York, New York, United States
• Wake Forest Baptist Health — Winston-Salem, North Carolina, United States
• Sarah Cannon Research Institute - Tennessee Oncology — Nashville, Tennessee, United States
• Sarah Cannon Research Institute - Texas Transplant Institute — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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