Maternal-fetal Immune Responses to Fetal Surgery

Completed

Conditions studied: Spina Bifida, Congenital Diaphragmatic Hernia, Lower Urinary Tract Obstructive Syndrome, Myelomeningocele

In brief

Performing surgery in utero on fetuses with certain birth defects has led to significant improvements in outcomes after birth; however, many of these infants are born preterm which can decrease the effectiveness of these procedures. The investigators aim to understand the effects of surgery on the maternal and fetal immune system and whether immune activation may be causing some of these infants to be born prematurely.

Key facts

Study ID

NCT04484441

Run by

Mayo Clinic

People needed

21

Starts

2022-03-24

Expected to finish

2025-12-01

Last updated by the study team

2026-02-10

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: not accepted.

You may not qualify if…

• Delivery planned elsewhere
• Abnormal fetal karyotype

Where it is running

• Mayo Clinic in Rochester, Minnesota — Rochester, Minnesota, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• University of Texas Houston — Houston, Texas, United States

Full record on ClinicalTrials.gov

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