A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors

Running, not enrolling · Phase 2

Conditions studied: Part 1: Bladder, Biliary Tract, Cervical, Endometrial, Ovarian, Pancreatic Cancer, Rare Tumors, Any Tumor Type Excluding Breast, Gastric, Colorectal Cancer, Part 2: HER2 Expressing/Amplified Solid Tumors Excluding Breast, Gastric, Colorectal Cancer

In brief

This is an open-label, multi-center, multi-cohort, Phase 2 study to evaluate the efficacy and safety of trastuzumab deruxtecan (T-DXd) for the treatment of selected HER2-expressing tumors. This study will consist of Part 1 which includes 7 cohorts of: urothelial bladder cancer, biliary tract cancer, cervical cancer, endometrial cancer, ovarian cancer, pancreatic cancer, and rare tumors; and Part 2 which includes 5 cohorts A to E of: A) any tumor type that is HER2 IHC 3+ (excluding breast, gastric cancer, and colorectal cancer), B) any tumor type that is HER2 IHC 2+/ISH+ (excluding breast, gastric cancer, and colorectal cancer), C) HER2 IHC 2+ or 1+ endometrial cancer, D) HER2 IHC 2+ or 1+ ovarian cancer, and E) HER2 IHC 2+ or 1+ cervical cancer. Study hypothesis: Trastuzumab deruxtecan will show meaningful clinical activity and a favorable risk benefit profile in selected HER2-expressing solid tumors.

Key facts

Study ID

NCT04482309

Run by

AstraZeneca

People needed

477

Starts

2020-08-18

Expected to finish

2027-03-23

Last updated by the study team

2026-07-10

Who can join

Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Locally advanced, unresectable, or metastatic disease based on most recent imaging.
• Part 1:The respective cohorts for patient inclusion are:
• Cohort 1: Biliary tract cancer
• Cohort 2: Bladder cancer
• Cohort 3: Cervical cancer
• Cohort 4: Endometrial cancer
• Cohort 5: Epithelial ovarian cancer
• Cohort 6: Pancreatic cancer
• Cohort 7: Rare tumors: This cohort will consist of patients with tumors that express HER2, excluding the tumors mentioned above, and breast, non-small cell lung cancer, gastric cancer, and colorectal cancer.
• Part 2:The respective cohorts for patient inclusion are:
• Cohort A: Metastatic or advanced solid tumors that are HER2 IHC 3+ (excluding breast, gastric cancer, and colorectal cancer). Patients with non-small cell lung cancer can be included.
• Cohort B: Metastatic or advanced solid tumors that are HER2 IHC 2+/ISH+ any tumor type (excluding breast, gastric cancer, and colorectal cancer). Patients with non-small cell lung cancer can be included.
• Cohort C: Metastatic or advanced solid endometrial cancer that is HER2 IHC 2+ or 1+.
• Cohort D: Metastatic or advanced ovarian cancer that is HER2 IHC 2+ or 1+.
• Cohort E: Metastatic or advanced solid cervical cancer that is HER2 IHC 2+ or 1+.
• Progressed following prior treatment or who have no satisfactory alternative treatment option.
• Prior HER2 targeting therapy is permitted.
• HER2 expression scored using current ASCO/CAP guidelines for scoring HER2 for gastric cancer.
• Part 1: IHC 3+ or IHC 2+ by local or central assessment
• Part 2: IHC and ISH results by central assessment as pre-defined for each cohort
• Has measurable target disease assessed by the Investigator based on RECIST version 1.1.
• Has protocol- defined adequate organ function including cardiac, renal and hepatic function.

You may not qualify if…

• History of non-infectious pneumonitis/ILD that required steroids, current ILD, or where suspected ILD that cannot be ruled out by imaging at screening
• Lung-specific intercurrent clinically significant severe illnesses
• Uncontrolled infection requiring intravenous (IV) antibiotics, antivirals, or antifungals
• Pleural effusion, ascites or pericardial effusion that requires drainage, peritoneal shunt, or Cell-free and Concentrated Ascites Reinfusion Therapy (CART
• Known Somatic DNA mutation of HER2 (ERBB2) without tumoral HER2 protein expression.
• Primary diagnosis of adenocarcinoma of the breast, adenocarcinoma of the colon or rectum, adenocarcinoma of the gastric body or gastro-esophageal junction, or non-small cell lung cancer for Part 1. For Part 2, patients with primary diagnosis of adenocarcinoma of the breast, adenocarcinoma of the colon or rectum, adenocarcinoma of the gastric body or gastro-esophageal junction will be excluded.
• Medical conditions that may interfere with the subject's participation in the study.

Where it is running

• Research Site — Santa Rosa, California, United States
• Research Site — Chicago, Illinois, United States
• Research Site — Muncie, Indiana, United States
• Research Site — Boston, Massachusetts, United States
• Research Site — Middletown, New Jersey, United States
• Research Site — Harrison, New York, United States
• Research Site — New York, New York, United States
• Research Site — New York, New York, United States
• Research Site — Durham, North Carolina, United States
• Research Site — Houston, Texas, United States
• Research Site — Seattle, Washington, United States
• Research Site — Auchenflower, Australia
• Research Site — Blacktown, Australia
• Research Site — Camperdown, Australia
• Research Site — Heidelberg, Australia
• Research Site — Melbourne, Australia
• Research Site — Nedlands, Australia
• Research Site — Brussels, Belgium
• Research Site — Leuven, Belgium
• Research Site — Liège, Belgium
• Research Site — Porto Alegre, Brazil
• Research Site — São Paulo, Brazil
• Research Site — Vitória, Brazil
• Research Site — Kelowna, British Columbia, Canada
• Research Site — Duarte, California, United States

Full record on ClinicalTrials.gov

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