Preventative Skin Care for Children Undergoing Targeted CNS Tumor Therapy

Completed · Phase 2

Conditions studied: Pediatric Cancer, CNS Tumor, Childhood, Skin Inflammation

In brief

This research study is examining a preventive skin care regimen for children diagnosed with a brain tumor and receiving anti-cancer therapy with a MEK, Pan-RAF, or BRAF inhibitor.

Key facts

Study ID

NCT04479514

Run by

Dana-Farber Cancer Institute

People needed

14

Starts

2020-10-01

Expected to finish

2025-02-15

Last updated by the study team

2026-06-12

Who can join

Age: 1 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with a brain tumor between ages 6 months old -18 years old and will undergo treatment with at least one of the following:
• Targeted BRAF inhibitor therapy to treat the brain tumor
• Targeted MEK inhibitor therapy to treat the brain tumor
• Targeted pan-RAF inhibitor therapy to treat the brain tumor
• Subjects may participate in other studies, including therapeutic trials.
• Ability to comply with PSCR including sun protection, gentle skin care and every other day dilute bleach baths.
• Ability to understand and/or the willingness of their parent or legally authorized representative to sign a written informed consent document.

You may not qualify if…

• Diagnosed with brain tumor at > 18 years old
• No data in medical records regarding treatment exposures
• Treated with a BRAF, MEK or pan-RAF inhibitor in the last three months
• Past or present allergic reaction to bleach
• Past or present allergic reactions to sunscreen and/or creams, lotions, emollients to be utilized in this study

Where it is running

• Boston Children's Hospital — Boston, Massachusetts, United States
• Dana-Farber Cancer Institute — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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