PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
Recruiting now
Conditions studied: Parkinson Disease
In brief
The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of Parkinson's disease (PD) progression in study participants with manifest PD, prodromal PD, and healthy controls. The overall goal of PPMI is to identify markers of disease progression for use in clinical trials of therapies to reduce progression of PD disability.
Key facts
- Study ID
- NCT04477785
- Run by
- Michael J. Fox Foundation for Parkinson's Research
- People needed
- 4500
- Starts
- 2020-07-01
- Expected to finish
- 2033-12-01
- Last updated by the study team
- 2026-07-27
Who can join
Age: 30 and older. Sex: any. Healthy volunteers: accepted.
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States (enrolling)
- Barrow Neurological Institute — Phoenix, Arizona, United States (enrolling)
- Mayo Foundation for Medical Education and Research — Scottsdale, Arizona, United States (enrolling)
- Banner Research Institute — Sun City, Arizona, United States (enrolling)
- University of California San Diego — La Jolla, California, United States (enrolling)
- Keck School of Medicine of USC — Los Angeles, California, United States (enrolling)
- University of California, San Francisco — San Francisco, California, United States (enrolling)
- University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States (enrolling)
- Institute For Neurodegenerative Disorders — New Haven, Connecticut, United States (enrolling)
- Parkinson's Disease& Movement Disorder Center of Boca Raton — Boca Raton, Florida, United States (enrolling)
- University of Florida — Gainesville, Florida, United States (enrolling)
- University of South Florida — Tampa, Florida, United States (enrolling)
- Emory University School of Medicine — Atlanta, Georgia, United States (enrolling)
- Northwestern University — Chicago, Illinois, United States (enrolling)
- University of Kansas Medical Center — Kansas City, Kansas, United States (enrolling)
- Johns Hopkins University — Baltimore, Maryland, United States (enrolling)
- Boston University — Boston, Massachusetts, United States (enrolling)
- Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
- University of Michigan — Ann Arbor, Michigan, United States (enrolling)
- Cleveland Clinic Lou Ruvo Center for Brain Health — Las Vegas, Nevada, United States (enrolling)
- Beth Israel Medical Center — New York, New York, United States (enrolling)
- NYU Langone Health — New York, New York, United States (enrolling)
- University of Rochester — Rochester, New York, United States (enrolling)
- University of Cincinnati/Cincinnati Children's Hospital — Cincinnati, Ohio, United States (enrolling)
- Cleveland Clinic — Cleveland, Ohio, United States (enrolling)
Full record on ClinicalTrials.gov
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