Cortical Priming to Optimize Gait Rehabilitation in Stroke: a Renewal

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Stroke

In brief

Achieving functional ambulation post stroke continues to be a challenge for stroke survivors, clinicians, and researchers. In the effort to enhance outcomes of motor training, cortical priming using brain stimulation has emerged as a promising adjuvant to conventional rehabilitation. This project focuses on the development of a long term gait rehabilitation protocol using brain stimulation to improve walking outcomes in people with stroke. The project will also aim to understand the neural mechanisms that are associated with response to the intervention.

Key facts

Study ID

NCT04477330

Run by

University of Illinois at Chicago

People needed

100

Starts

2020-09-01

Expected to finish

2027-08-31

Last updated by the study team

2026-05-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age greater than 18 years
• First ever monohemispheric stroke > 3 months since onset
• Residual hemiparetic gait deficits (e.g. abnormal gait pattern)
• Able to walk for 5 minutes at self-paced speed. Handheld assistive device is acceptable.
• Walking speed lesser than 1.2 m/s
• Lower limb Fugl-Meyer Motor score between 15-30
• At least 5 deg of ankle dorsiflexion necessary to perform the ankle-tracking task

You may not qualify if…

• General exclusion criteria
• Severe osteoporosis
• Contracture-limiting range of motion of lower limb
• Score of more than 2 on the Modified Ashworth Scale (indicating increased muscle tone through ankle range of motion)
• Uncontrolled anti-spasticity medications during the study period
• Score less than 6 on the Fugl-Meyer Sensory Assessment Scale for the Lower Limb
• Cardiorespiratory or metabolic diseases (e.g. cardiac arrhythmia, uncontrolled hypertension or diabetes, chronic emphysema)
• Unhealed decubiti, persistent infection
• Significant cognitive or communication impairment (Mini-Mental State Examination (MMSE)<21), which could impede the understanding of the purpose of procedures of the study or prevent the patient from performing the ankle-tracking task.
• Lesions involving the brainstem and cerebellum
• Failure to pass the graded exercise stress test
• TMS exclusion criteria
• Implanted cardiac pacemaker
• Metal implants in the head or face
• Unexplained, recurring headaches
• History of seizures or epilepsy
• Currently under medication that could increase motor excitability and lower seizure threshold
• Skull abnormalities or fractures
• Concussion within the last 6 months
• Currently pregnant
• tDCS exclusion criteria
• Skin hypersensitivity
• History of contact dermatitits
• History of allodynia and/or hyperalgesia
• Any other skin or scalp condition that could be aggravated by tDCS

Where it is running

• Physical Therapy — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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