Interactions Between Skincare Product Ingredients and the Skin Microbiome

Completed · Not applicable

Conditions studied: Dysbiosis

In brief

This is a study of the influence of skincare products containing chemicals such as parabens and phthalates on the skin microbiome.

Key facts

Study ID

NCT04476732

Run by

University of California, Davis

People needed

19

Starts

2020-02-11

Expected to finish

2020-07-16

Last updated by the study team

2020-08-03

Who can join

Age: 15 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Individuals aged 15 and over
• No known medical conditions that, in the investigator's opinion, may interfere with study participation.

You may not qualify if…

• Individuals who have been on any medication (including antibiotics, probiotics, prebiotics) that has caused a change in current skin composition of interest based on the opinion of the investigator.
• Individuals with systemic antibiotic use within last 60 days.
• Individuals with topical antibiotic use on the test sites within last 30 days
• Individuals unwilling/unable to avoid topical antibiotics, systemic antibiotics, prebiotics, and probiotics during study.
• No other interfering skin products should be used during duration of study. (Paraben-free \& phthalate-free personal product "safe" list will be provided for other uses during study period if needed).
• Individuals unwilling or unable to undergo 1 week wash-in with paraben/phthalate-free products if needed in the opinion of the investigator.
• Female volunteers who are pregnant or are actively breastfeeding or planning a pregnancy within two months. (There is no known concern for risk to fetus but pregnancy can alter the microbiome being studied)
• Female volunteers who have started a new hormonal birth control agent or switched to a hormonal birth control agent within the past 60 days
• Individuals using any interfering skin products in the opinion of the investigator within 2 weeks of enrollment into the study.
• Individuals who have participated in any other clinical studies using the same test sites (face) in the past 14 days
• Individuals with a known history of hypersensitivity to any ingredients to the cosmetic agent that is being assessed
• Individuals who have history of a psychological illness or condition that would interfere with their ability to understand and follow the requirements of the study at the discretion of the investigator.

Where it is running

• UC Davis Dermatology Department — Sacramento, California, United States

Full record on ClinicalTrials.gov

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