Impact of Coronary Artery Stenting on Quantitative Myocardial Blood Flow and Health Status
Status unconfirmed
Conditions studied: Coronary Artery Disease
In brief
We propose to perform PET MPI studies in patients before and after stenting to evaluate changes (or lack thereof) in MBFR and how that is associated with changes (or lack thereof) in symptoms, functional status and quality of life. This will help to understand the role of MBFR in patient selection for coronary angiography and stenting.
Key facts
- Study ID
- NCT04475094
- Run by
- Cardiovascular Imaging Technologies
- People needed
- 75
- Starts
- 2019-12-23
- Expected to finish
- 2021-12-31
- Last updated by the study team
- 2020-07-17
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- The index clinically-indicated rest/regadenoson stress myocardial perfusion PET study shows at least one reversible perfusion defect; and
- The MBFR measurement meets quality control criteria for accuracy; and
- The patient has completed a baseline SAQ-7 and RDS survey with a SAQ-7 Angina Frequency Score <100 (indicating the occurrence of at least some angina symptoms over the past 4 weeks); and
- The patient has undergone a successful coronary artery stenting within 60 days after the PET scan without a significant change in clinical condition between the time of baseline PET MPI test and PCI; and 5. The patient agrees to undergo a second PET scan 3-6 weeks after coronary artery stenting and to complete a second SAQ-7 and RDS survey.
You may not qualify if…
- EF <40%
- Significant aortic stenosis/regurgitation
- Significant Mitral stenosis/regurgitation)
- Prior CABG
- Poor quality base line PET study due one or more technical challenges (e.g. patient motion, imprecise registration of CT and emission data, flows that violate quality criteria, lack of flow augmentation suggestive of an A2A antagonist)
Where it is running
- Saint Luke's Hospital Imaging Center — Kansas City, Missouri, United States (enrolling)
Full record on ClinicalTrials.gov
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