Sputum Studies of Anti-Citrullinated Protein Antibodies (ACPA) and Rheumatoid Arthritis (RA) Origins

Completed

Conditions studied: Rheumatoid Arthritis

In brief

The study is designed to learn more about the causes of rheumatoid arthritis (RA). People who get RA have elevated protein markers called autoantibodies in their blood years before initial symptoms of arthritis. The goal of this study is to learn more about how autoantibodies in RA might be related to inflammation in the lungs.

Key facts

Study ID

NCT04474392

Run by

University of Colorado, Denver

People needed

340

Starts

2020-08-01

Expected to finish

2026-01-14

Last updated by the study team

2026-06-16

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults between 18 and 100 years;
• At-Risk for RA, RA diagnosed, and Healthy Control subjects will be included in the study until recruitment goals are met for each group.
• At-Risk:
• No evidence of inflammatory arthritis on clinical examination AND
• At elevated risk for RA based on familial or serologic risk
• Familial risk includes having a first degree relatives (FDRs) with RA
• Serologic risk includes asymptomatic serum ACPA positivity
• Healthy Controls :
• No history of RA
• No FDRs with RA
• No systemic use of immunosuppressants for autoimmune disease
• RA Diagnosis:
• Classified RA by 1987 ACR and/or 2010 ACR/EULAR RA classification criteria (confirmed by medical chart review) OR
• Diagnosed with RA by a board-certified rheumatologist (confirmed by medical chart review)

You may not qualify if…

• Currently pregnant or planning to become pregnant during the sample collection period of the study
• Exacerbation of underlying obstructive lung disease within the past 1 month
• Known FEV1 <1 liter
• Oxygen requirement >2 liters at rest
• Participants with health acuity or behavioral health concerns leaving them unable to participate in the current research
• Note: If a subject temporarily does not meet inclusion criteria but is interested in participating, he/she may participate once inclusion criteria have been met.
• If interested, please take a few minutes to complete the screening questionnaire for this study opportunity. You may open the survey in your web browser by clicking the link below:
• https://is.gd/SPAROscreen
• If the link above does not work, try copying the link below into your web browser:
• https://redcap.ucdenver.edu/surveys/?s=3WM8WH3WKK

Where it is running

• University of Colorado Denver (Anschutz Medical Campus) — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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