Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study

Recruiting now

Conditions studied: Prostate Carcinoma

In brief

This study investigates ways to detect prostate cancer earlier in people at genetic risk for disease that forms, grows, or spreads quickly (aggressive). Studying samples of blood, urine, and/or tissue in the laboratory may help doctors further understand the genetics of prostate cancer and help identify ways to detect cancer earlier, thereby improving treatment and methods of early detection in the future.

Key facts

Study ID

NCT04472338

Run by

University of Washington

People needed

450

Starts

2020-05-21

Expected to finish

2030-08-31

Last updated by the study team

2026-05-15

Who can join

Age: 40 and older. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• People with prostates ≥40 years of age
• Documented germline pathogenic variant in known or suspected genes associated with prostate cancer risk.

You may not qualify if…

• Prior diagnosis of prostate cancer
• Medical contraindication to any of the study procedures (e.g., prostate biopsy)
• For all cancer types except non-melanoma skin cancer, any cancer treatment with curative intent within the past 12 months (e.g., surgery, radiation, chemotherapy, immunotherapy)
• Prior or concurrent participation in an interventional clinical trial aimed at preventing cancer for people with germline variants associated with increased prostate cancer risk
• Unable to provide written informed consent
• Unable or unwilling to complete clinical care and study procedures as indicated by the study protocol.

Where it is running

• Fred Hutch/University of Washington Cancer Consortium — Seattle, Washington, United States (enrolling)
• University of California, San Francisco — San Francisco, California, United States (enrolling)
• Northwestern — Chicago, Illinois, United States (enrolling)
• Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
• OHSU Knight Cancer Institute — Portland, Oregon, United States (enrolling)
• University of Pennsylvania/Abramson Cancer Center — Philadelphia, Pennsylvania, United States (enrolling)
• City of Hope — Duarte, California, United States (enrolling)
• University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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