Effects of Multi-day Interruptions in Sitting on Type 2 Diabetes-relevant Outcomes in Children

Running, not enrolling · Not applicable

Conditions studied: Sedentary Behavior, Affect, Metabolic Disturbance, Anxiety, Cardiac Autonomic Nervous System Function

In brief

The overall objective of this in-lab randomized controlled trial is to test the efficacy of multi-day interruptions in sedentary behavior vs. single bouts of sustained exercise on metabolic, cognitive, affective, and cardiac autonomic nervous system responses in children with overweight and obesity who are at risk for type 2 diabetes. The use of continuous glucose monitoring will provide insight into the daily and cumulative metabolic effects of each condition that have thus far not been studied. In-lab studies demonstrating sustained efficacy of this approach in ameliorating negative effects of sedentary behaviors in children are necessary for the optimization of field-based interventions. Given the lack of success of interventions to prevent obesity-related diseases and increasing rates of type 2 diabetes in children and its related healthcare costs, this study addresses a critical public health need by testing of novel intervention strategies to reduce obesity-related diseases in children with overweight and obesity.

Key facts

Study ID

NCT04469790

Run by

University of Southern California

People needed

188

Starts

2022-03-01

Expected to finish

2026-08-31

Last updated by the study team

2026-06-15

Who can join

Age: 8 and older, up to 11. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 8-11 years-old
• Good general health
• BMI≥85th percentile

You may not qualify if…

• Significant cardiac or pulmonary disease likely to or resulting in hypoxia or decreased perfusion
• Diagnosis of T2DM and/or presence of other endocrinologic disorders leading to obesity (e.g., Cushing Syndrome)
• Current or past anti-psychotic drug use that would affect metabolism
• Non-diet treatment for hypertension or dyslipidemia
• Precocious puberty and/or receiving androgen and estrogen therapy
• Medication use known to affect body composition/weight

Where it is running

• Britni Ryan Belcher, PhD, MPH — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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