Impact of Sinus Surgery on Individuals With Cystic Fibrosis

Recruiting now

Conditions studied: Chronic Rhinosinusitis (Diagnosis), Cystic Fibrosis

In brief

This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS). Individuals who do not undergo surgery but are treated medically for CRS will also be enrolled to serve as a control group. Outcomes analyzed will include pulmonary, quality of life, and others.

Key facts

Study ID

NCT04469439

Run by

University of California, Los Angeles

People needed

170

Starts

2020-07-01

Expected to finish

2027-01-31

Last updated by the study team

2026-04-22

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects between the ages of 18 years old (inclusive) and 99 years old (inclusive, subjects over the age of 89 will be recorded to be 89 years old).
• Diagnosed with cystic fibrosis as established by genetic testing combined with clinical assessment and/or sweat chloride
• Diagnosed with chronic rhinosinusitis by multidisciplinary sinusitis guidelines
• chronic rhinosinusitis symptoms persisting beyond initial medical treatment
• Counseled for endoscopic sinus surgery and ongoing medical therapy with each patient electing their preferred treatment

You may not qualify if…

• Underwent endoscopic sinus surgery in past 12 months
• Will obtain follow up care at non-participating institutions
• Unable to complete follow-up surveys

Where it is running

• University of California, Los Angeles — Los Angeles, California, United States (enrolling)
• Stanford University — Stanford, California, United States (enrolling)
• University of Colorado — Aurora, Colorado, United States (enrolling)
• National Jewish Health — Denver, Colorado, United States (enrolling)
• University of North Carolina — Chapel Hill, North Carolina, United States (enrolling)
• Oregon Health Science University — Portland, Oregon, United States (enrolling)
• Medical University of South Carolina — Charleston, South Carolina, United States (enrolling)
• Vanderbilt University Medical Center — Nashville, Tennessee, United States (enrolling)
• University of Utah — Salt Lake City, Utah, United States (enrolling)

Full record on ClinicalTrials.gov

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