Measuring Cell-Free DNA (cfDNA) Levels in People With Follicular Lymphoma
Running, not enrolling · Phase 1
Conditions studied: Follicular Lymphoma
In brief
The researchers are doing this study to measure and test cell-free DNA (cfDNA) in the blood before, during, and after first-line treatment for follicular lymphoma. They will look at whether cfDNA levels are related to a person's response to the usual first-line treatment for follicular lymphoma. Researchers also want to understand how different genetic changes in follicular lymphoma relate to a person's response to the usual first-line treatment.
Key facts
- Study ID
- NCT04468841
- Run by
- Memorial Sloan Kettering Cancer Center
- People needed
- 77
- Starts
- 2020-07-08
- Expected to finish
- 2026-07-01
- Last updated by the study team
- 2026-06-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ≥18 years of age at time of signing informed consent. Consent is permitted from either the participant or from a Legally Authorized Representative (LAR) on their behalf.
- Histology-confirmed follicular lymphoma grade 1-3a, verified by the enrolling institution
- Ability to adhere to the study visit schedule and all the protocol requirements
- Measurable FDG-avid disease
- Not applicable for retrospective patients in CR
You may not qualify if…
- Patients receiving second or greater line of therapy (except in retrospective cohort of long-term survivors of FL [i.e. >10 years out from frontline treatment])
Where it is running
- Memorial Sloan Kettering Basking Ridge (All Protocol Activities) — Basking Ridge, New Jersey, United States
- Memorial Sloan Kettering Monmouth (All protocol activities) — Middletown, New Jersey, United States
- Memorial Sloan Kettering Bergen (All protocol Activities) — Montvale, New Jersey, United States
- Memorial Sloan Kettering Commack (All Protocol Activities) — Commack, New York, United States
- Memorial Sloan Kettering Westchester (All Protocol Activities) — East White Plains, New York, United States
- Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States
- Memorial Sloan Kettering Nassau (All Protocol Activities) — Uniondale, New York, United States
Full record on ClinicalTrials.gov
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