Effect of Pre-existing Adjacent Segment Degeneration on Long-term Effectiveness After Lumbar Fusion Surgery

Recruiting now

Conditions studied: Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease, Degeneration Spine

In brief

This is a prospective single-center study. Patients requiring posterior lumbar interbody fusion (PLIF) for lumbar degenerative disease are prospectively enrolled and followed. Important adjacent pre-existing degeneration factors include discs degenerated, facets and ligamentum flavum tropism which could lead to spinal canal stenosis (SCS). This study will focus on the effects of pre- existing adjacent degeneration (disc factors and spinal canal stenosis factors) on long-term postoperative outcomes.

Key facts

Study ID

NCT04467944

Run by

Peking University Third Hospital

People needed

210

Starts

2018-01-01

Expected to finish

2032-12-31

Last updated by the study team

2020-07-13

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A clear diagnosis of lumbar spinal stenosis, and surgical level of L4- S1 (The levels to be operated on were decided by matching the clinical symptomatology with the radiological findings of the spinal levels that needed decompression);
• Failed at least eight weeks conservative treatment;

You may not qualify if…

• Unstable factors (slip, rotation, lateral bending, etc.) in adjacent segment L3/4;
• Preoperative sagittal and coronal imbalance of the spine;
• Lumbar infection and/or tumor diseases;
• A previous history of lumbar fusion surgery.

Where it is running

• Peking University Third Hospital — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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