Biomarkers of CASH
Running, not enrolling
Conditions studied: Cerebral Cavernous Malformation, Cavernous Angioma, Hemorrhagic Microangiopathy
In brief
The project aims to develop prognostic and diagnostic blood tests for symptomatic brain hemorrhage in patients diagnosed with cavernous angiomas, a critical clinical challenge in a disease affecting more than a million Americans. We further examine whether blood biomarkers can replace or enhance the accuracy of advanced imaging in association with lesional bleeding. The project tests a novel integrational approach of biomarker development in a mechanistically defined cerebrovascular disease, with a clinically relevant context of use.
Key facts
- Study ID
- NCT04467489
- Run by
- University of Chicago
- People needed
- 1040
- Starts
- 2020-05-22
- Expected to finish
- 2026-06-30
- Last updated by the study team
- 2025-08-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Clinical diagnosis of CA
- age 18 or older
- solitary or multiple
- familial or sporadic
- with or without prior symptoms
You may not qualify if…
- Prior excision of a solitary CA lesion
- prior stereotactic radiosurgery or any brain irradiation
- spinal cavernoma without brain lesion
- other brain pathology unrelated to CA (demyelinating disease, brain tumor)
- seizures or stroke unrelated to CA in the prior year
- current pregnancy or within 6 months postpartum
- reluctance to undergo venipuncture or donate blood specimen, or be called for clinical follow-up for up to one year
- homeless or incarcerated persons, or other reason a subject will be unable/unlikely to be reached for follow-up
- Aim 3:
- Inclusion Criteria:
- < 30 years of age
- one or more seizures (with or without medical therapy) in the prior year
- OR
- > 50 years of age
- having received an MRI of the brain with SWI (susceptibility weighted imaging) sequences for any indication in the year prior to enrollment
- No HMA on brain MRI SWI sequences
- OR
- > 50 years of age
- having received an MRI of the brain with SWI sequences for any indication in the year prior to enrollment
- Two or more microbleeds on SWI brain MRI sequences, adjudicated by neuroradiologist
- Exclusion Criteria:
- concurrent brain disease or structural brain pathology
- medical illness requiring hospitalization or surgery, seizure or stroke in the prior 12 months
- active use of prescription medications in the prior 12 months
- current pregnancy or within 6 months postpartum
Where it is running
- Barrow Neurological Institute at St. Joseph's Hospital and Medical Center — Phoenix, Arizona, United States
- University of California, San Francisco — San Francisco, California, United States
- The University of Chicago Medical Center — Chicago, Illinois, United States
- Mayo Clinic — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.