A Study of NGM621 in Participants With Geographic Atrophy

Completed · Phase 2 · Has a placebo group

Conditions studied: Geographic Atrophy

In brief

This is a multi-center evaluation of NGM621 in a randomized, double-masked, sham-controlled study in participants with Geographic Atrophy secondary to Age-related Macular Degeneration.

Key facts

Study ID

NCT04465955

Run by

NGM Biopharmaceuticals, Inc

People needed

320

Starts

2020-07-22

Expected to finish

2022-08-16

Last updated by the study team

2025-07-01

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female (non-pregnant, non-lactating) subjects ≥ 55 years
• Standard luminance BCVA score of 34 letters or better using ETDRS charts at the starting distance of 4 meters (approximately 20/200 Snellen equivalent or better) in study eye
• Clinical diagnosis of GA secondary to AMD:
• Total GA area must be ≥ 2.5 and ≤ 17.5 mm²
• If GA is multifocal, at least one focal lesion must be ≥ 1.25 mm² (0.5 DA), with the overall area of GA ≥ 2.5 and ≤ 17.5 mm²
• Well demarcated GA with no anatomical evidence of current or prior CNV in the study eye

You may not qualify if…

• Study Eye
• GA secondary to a condition other than AMD in either eye (e.g., monogenetic macular dystrophies like Stargardt disease, cone rod dystrophy, or toxic maculopathies)
• Any history of or active choroidal neovascularization (CNV)
• Both Eyes
• Any history of or active bacterial, viral, fungal, or parasitic infection in either eye in the 3 months prior to randomization

Where it is running

• California Retina Consultants — Bakersfield, California, United States
• Retina Vitreous Associates — Beverly Hills, California, United States
• Retinal Diagnostic Center — Campbell, California, United States
• The Retina Partners — Encino, California, United States
• Retina Consultants of Orange County — Fullerton, California, United States
• Loma Linda University Health — Loma Linda, California, United States
• University of California Los Angeles — Los Angeles, California, United States
• Northern California Retina Vitreous Associates — Mountain View, California, United States
• Retina Institute of California — Palm Desert, California, United States
• California Eye Specialists — Pasadena, California, United States
• Retina Consultants San Diego — Poway, California, United States
• Retinal Consultants Medical Group Inc — Sacramento, California, United States
• University of California San Francisco — San Francisco, California, United States
• Orange County Retina Medical Group — Santa Ana, California, United States
• California Retina Consultants — Santa Barbara, California, United States
• Retina Consultants of Southern Colorado PC — Colorado Springs, Colorado, United States
• Colorado Retina Associates PC — Golden, Colorado, United States
• New England Retina Associates PC — Waterford, Connecticut, United States
• Florida Eye Microsurgical Institute — Boynton Beach, Florida, United States
• University of Miami — Coral Gables, Florida, United States
• Specialty Retina Center (Coral Springs) — Coral Springs, Florida, United States
• Retina Group of Florida — Fort Lauderdale, Florida, United States
• National Ophthalmic Research Institute — Fort Myers, Florida, United States
• Florida Eye Associates — Melbourne, Florida, United States
• Associated Retina Consultants — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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