SMART Effectiveness Trial

Completed · Not applicable

Conditions studied: Opioid-use Disorder, Opioid Dependence, Treatment Adherence

In brief

The current study piloted two psychosocial interventions developed to increase buprenorphine-naloxone adherence in individuals with opioid use disorder (OUD). Participants were randomized to receive either contingency management (CM) or a brief substance free activities session plus mindfulness (BSM) cognitive-behavioral intervention. Participants were 48 newly presenting patients from an OUD treatment clinic. The primary outcome was medication adherence, as measured by buprenorphine metabolite in urine and presence at 2 or more of 4 possible physician visits.

Key facts

Study ID

NCT04464421

Run by

Karen Derefinko, PhD

People needed

48

Starts

2020-08-17

Expected to finish

2021-08-29

Last updated by the study team

2025-12-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Present for an intake appointment at study site for treatment of opioid use disorder.
• Eligible for receipt of buprenorphine-naloxone treatment (e.g. Suboxone, Bunavil, Zubsolv) as determined by clinic physicians
• 18 years or older
• Willing to be randomized to one of the two intervention arms
• Ability to comprehend consent and intervention materials (approximately 8th-grade level).

Where it is running

• University of Tennessee Health Science Center — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.