RecruitmEnt Assessed by eleCtRical Impedance Tomography

Recruiting now

Conditions studied: Acute Respiratory Distress Syndrome (ARDS)

In brief

The RECRUIT study is a multinational, multicenter physiological observational study conducted by the PLUG working group. It is a single-day study (1.5-2 hours) associated with specific lung (de)recruitment maneuvers to verify the feasibility of measuring the potential for lung recruitment in mechanically ventilated patients with ARDS by electrical impedance tomography (EIT).

Key facts

Study ID

NCT04460859

Run by

Unity Health Toronto

People needed

171

Starts

2020-06-09

Expected to finish

2027-06-01

Last updated by the study team

2025-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Intubated moderate and severe ARDS according to the Berlin definition (PaO2/FiO2 ratio <= 200 mmHg)
• Under continuous sedation with or without paralysis

You may not qualify if…

• Age <18 years
• Bronchopleural fistula
• Pure COPD exacerbation
• Contraindication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode belt placement)
• Hemodynamic instability (Systolic BP < 75 mmHg or MAP < 60 mmHg despite vasopressors and/or heart rate < 55 bpm)
• Attending physician deems the transient application of high airway pressures to be unsafe

Where it is running

• Faculdade de Medicina da University São Paulo — São Paulo, Brazil (enrolling)
• St. Michael's Hospital — Toronto, Ontario, Canada (enrolling)
• Vall d'Hebron University Hospital — Barcelona, Spain (enrolling)
• Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico — Milan, Italy

Full record on ClinicalTrials.gov

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