Fiber Metabolism in Chronic Obstructive Pulmonary Disease
Completed · Not applicable · Has a placebo group
Conditions studied: Chronic Obstructive Pulmonary Disease, Aging
In brief
The impact of fiber intake on short chain fatty acid (SCFA) metabolism has not been studied in subjects suffering from COPD. The purpose of this study is to compare changes in SCFA metabolism after inulin vs. placebo intake in COPD patients to healthy matched controls. This protocol is an extension of a recent study about whole-body SCFA production rates in COPD patients. The investigators hypothesize that a short-term fiber supplementation increases SCFA production in COPD patients.
Key facts
- Study ID
- NCT04459156
- Run by
- Texas A&M University
- People needed
- 87
- Starts
- 2020-06-23
- Expected to finish
- 2023-03-10
- Last updated by the study team
- 2025-09-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy male or female according to the investigator's or appointed staff's judgment
- Ability to walk, sit down and stand up independently
- Age 45 - 100 years for healthy control subjects
- Age 18 - 30 years for healthy, young adults
- Ability to lay in supine or elevated position for 1.5 hours
- No diagnosis of COPD
- Willingness and ability to comply with the protocol
- Inclusion criteria COPD subjects:
- Ability to walk, sit down and stand up independently
- Age 45 - 100 years
- Ability to lie in supine or elevated position for 1.5 hours
- Diagnosis of moderate to very severe chronic airflow limitation and compliant to the following criteria: FEV1 < 70% of reference FEV1
- Clinically stable condition and not suffering from a respiratory tract infection or exacerbation of their disease (defined as a combination of increased cough, sputum purulence, shortness of breath, systemic symptoms such as fever, and a decrease in FEV1 > 10% compared with values when clinically stable in the preceding year) at least 4 weeks prior to the first test day
- Shortness of breath on exertion
- Willingness and ability to comply with the protocol
- Exclusion criteria all subjects:
- Any condition that may interfere with the definition 'healthy subject' according to the investigator's judgment (healthy subjects only)
- Insulin dependent diabetes mellitus
- Established diagnosis of malignancy
- History of untreated metabolic diseases including hepatic or renal disorder
- Presence of acute illness or metabolically unstable chronic illness
- Presence of fever within the last 3 days
- Use of short course of oral corticosteroids within 4 weeks preceding study day
- Dietary or lifestyle characteristics:
- Daily use of fiber supplements 1 week prior to the first test day
Where it is running
- Texas A&M University-CTRAL — College Station, Texas, United States
Full record on ClinicalTrials.gov
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