Genetic and Dietary Predictors of Anti-platelet Response

Stopped early · Phase 4

Conditions studied: Platelet Function

In brief

This study will investigate differences in platelet aggregation under basal and aspirin-treated conditions in American Indian and Alaska Native people who have extreme levels (low and high) of n-3 polyunsaturated fatty acids (n-3 PUFAs, EPA and DHA) in red blood cell membranes. The study will also determine whether or not platelet aggregation under the different conditions is modified by CYP4A11, CYP4F2, CYP4F11, PEAR1, and ACTN1 gene variation.

Key facts

Study ID

NCT04456608

Run by

University of Washington

People needed

126

Starts

2016-08-01

Expected to finish

2023-07-31

Last updated by the study team

2023-12-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participants with no history of significant medical conditions including cardiac, pulmonary, hepatic, gastrointestinal, or renal disease, or HIV.
• Participants will be males or females, 18 years or older.
• Participants will be self-identified as: Yup'ik or Cup'ik (YK-Delta), AI/AN (SCF), or a member of the Confederated Salish and Kootenai Tribe (Flathead Reservation).
• Participants must read and understand English or Yup'ik.
• Participants must be able to provide informed consent.

You may not qualify if…

• Participants with any significant chronic medical condition, including cardiac, pulmonary, hepatic, gastrointestinal, or renal disease, or HIV.
• Participants less than 18 yrs of age.
• Participants unable to read and understand English or Yup'ik.
• Participants unable to provide informed consent.
• Recent (within 2 weeks) use of aspirin, NSAIDs, antihistamines, or any prescription anticoagulant drug such as warfarin.

Where it is running

• Southcentral Foundation — Anchorage, Alaska, United States
• University of Montana — Missoula, Montana, United States
• Oregon Health & Sciences University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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