Mechanisms of Increased Disease Severity in AD Patients With the IL-4Ra R576 Polymorphism
Recruiting now
Conditions studied: Atopic Dermatitis
In brief
This protocol is primarily looking to see if the IL-4Ra R576 polymorphism is associated with increased clinical, immunological and microbial markers of disease activity in patients with Atopic dermatitis.
Key facts
- Study ID
- NCT04455906
- Run by
- Boston Children's Hospital
- People needed
- 111
- Starts
- 2020-11-30
- Expected to finish
- 2027-09-15
- Last updated by the study team
- 2026-05-18
Who can join
Age: 6 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female participants ≥6 to 65 yrs of age
- Meet AD Standard Diagnostic Criteria
You may not qualify if…
- Enrollment in another clinical trial
- Hypersensitivity to an agent used for the skin decolonization protocol
- Use within 4 weeks of systemic treatment with immunosuppressive/immunomodulating drugs (corticosteroids, cyclosporine, mycophenolate, JAK inhibitors, azathioprine, methotrexate)
- Phototherapy for AD within 4 weeks
- Treatment with biologics (dupilumab, omalizumab, benralizumab, etc) within sixteen weeks
- Use of topical steroids, topical calcineurin inhibitors or crisaborale within 7 days
- Bleach baths within 7 days of the first Visit
- Use of oral or topical antibiotics within 21 days of the beginning of the study
- Asthmatics receiving more than 500 μg per day of inhaled corticosteroids
- History of (HIV, hepatitis B, hepatitis C, tuberculosis malignancy
- Skin comorbidities that may interfere with assessments: psoriasis, cutaneous T Cell lymphoma,,
- Severe ongoing medical illnesses e.g. cardiovascular, renal disease, autoimmune disease.
- Febrile illness at time of visits
- Suspected immune deficiency or family history of primary immunodeficiency
Where it is running
- Boston Children's Hospital — Boston, Massachusetts, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.