A Study Evaluating Treatment Intensification With ABI-H0731 in Participants With Chronic Hepatitis B Infection on Nucleos(t)Ide Reverse Transcriptase Inhibitors

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Chronic Hepatitis B

In brief

This study will explore the safety and antiviral activity of ABI-H0731 when added to a nucleos(t)ide reverse transcriptase inhibitor (NrtI) in participants who are partially virologically suppressed.

Key facts

Study ID

NCT04454567

Run by

Assembly Biosciences

People needed

2

Starts

2020-11-11

Expected to finish

2021-04-08

Last updated by the study team

2022-10-20

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Body mass index (BMI) 18 to 36 kg/m\^2 and a minimum body weight of 45 kg (inclusive)
• In good general health except for chronic hepatitis B (CHB)
• HBeAg positive or HBeAg negative chronic hepatitis B
• HBV DNA >LLOQ using a commercially available assay with LLOQ=20 IU/mL
• On a stable NrtI regimen (ETV, TDF or TAF) for more than 12 months
• Lack of cirrhosis or advanced liver disease

You may not qualify if…

• Current or prior treatment for CHB with lamivudine, telbivudine, adefovir, HBV core inhibitor, or previous treatment with an investigational agent for HBV infection
• Presence of substitutions in the HBV polymerase coding region which may confer reduced susceptibility to NrtIs
• Co-infection with human immunodeficiency virus, hepatitis A virus, hepatitis C virus, hepatitis E virus, or hepatitis D virus
• Females who are lactating or wish to become pregnant during the course of the trial
• History or evidence of advanced liver disease or hepatic decompensation
• Clinically significant cardiac disease including poorly-controlled or unstable hypertension; pulmonary disease; chronic or recurrent renal or urinary tract disease; liver disease other than CHB; endocrine disorder; autoimmune disorder; poorly controlled diabetes mellitus; neuromuscular, musculoskeletal, or mucocutaneous conditions requiring frequent treatment, seizure disorders requiring treatment; ongoing infection or other medical conditions requiring frequent medical management or pharmacologic or surgical treatment that, in the opinion of the Investigator or the Sponsor, makes the subject unsuitable for trial participation
• History of hepatocellular carcinoma (HCC)
• Exclusionary laboratory parameters at Screening:
• Platelet count <100,000/mm\^3
• Albumin <lower limit of normal
• Total bilirubin >1.2 × upper limit of normal (ULN)
• Direct bilirubin >1.2 × ULN
• ALT >10 × ULN
• Serum alpha fetoprotein (AFP) ≥100 ng/mL. If AFP at Screening is >ULN but <100 ng/mL, the participant is eligible if a hepatic imaging trial prior to initiation of study drug reveals no lesions indicative of possible HCC.
• International Normalized Ratio >1.5 × ULN
• Glomerular filtration rate <50 mL/min/1.73 m\^2 by Chronic Kidney Disease Epidemiology Collaboration equation
• Any other laboratory abnormality deemed clinically significant by the Sponsor or the Investigator.

Where it is running

• Asia Pacific Liver Center — Los Angeles, California, United States
• California Liver Research Institute — Pasadena, California, United States
• Research and Education — San Diego, California, United States
• Quest Clinical Research — San Francisco, California, United States
• Schiff Center for Liver Disease — Miami, Florida, United States
• Institute of Human Virology — Baltimore, Maryland, United States
• Infectious Disease Care — Hillsborough, New Jersey, United States
• Northwell Health — Manhasset, New York, United States
• Office of X.M., MD — Philadelphia, Pennsylvania, United States
• Prince of Wales Hospital — Hong Kong, Hong Kong
• Queen Mary Hospital — Hong Kong, Hong Kong
• Auckland Clinical Studies — Grafton, Auckland, New Zealand

Full record on ClinicalTrials.gov

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