A Study to Assess Safety and Efficacy of PRL3-Zumab in Patients With Solid Tumors

Running, not enrolling · Phase 2

Conditions studied: Solid Tumor

In brief

This is a multi-center, Phase 2, open-label, single dose level study of PRL3-zumab monotherapy in patients with unresectable or metastatic solid tumor.

Key facts

Study ID: NCT04452955
Run by: Intra-IMMUSG Pte Ltd
People needed: 51
Starts: 2020-12-12
Expected to finish: 2026-12-01
Last updated by the study team: 2026-04-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients with unresectable or metastatic solid tumors willing to provide signed informed consent.
Histopathological diagnosis and metastatic status cancer at study entry.
Must have received at least 1 prior line of systemic therapy for metastatic disease but no more than 3 prior lines of treatment for metastatic disease.
Life expectancy of more than 6 months.
Eastern Cooperative Oncology Group (ECOG) performance status (PS) score or less than 2.
Adequate organ and hematological function.
Measurable disease by RECIST v1.1 and iRECIST.

You may not qualify if…

Patient has known untreated or symptomatic central nervous system metastasis.
Patient is receiving systemic glucocorticoids or other immunosuppressive treatments for autoimmune disease or any other medical condition.
Patient has experienced a severe hypersensitivity reaction to another monoclonal antibody.
Patient has received treatment with any systemic anti-cancer therapies within 3 weeks prior to starting study treatment.
Patient has undergone radiotherapy ≤ 4 weeks prior to starting study treatment.
Patient has received > 3 lines of prior systemic chemotherapy for metastatic disease

Where it is running

HonorHealth Research — Scottsdale, Arizona, United States
St. Jude Medical Center — Fullerton, California, United States
The Angeles Clinic — Los Angeles, California, United States
Norton Healthcare — Louisville, Kentucky, United States
Comprehensive Cancer Centers of Nevada — Las Vegas, Nevada, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.