Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting

Recruiting now · Not applicable

Conditions studied: Infertility, Male, Cancer, Autoimmune Disorder

In brief

Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to gonadotoxic therapy. The purpose of this study is to test the safety and feasibility of these transplant technologies and restore fertility for these participants.

Key facts

Study ID

NCT04452305

Run by

University of Pittsburgh

People needed

10

Starts

2023-11-10

Expected to finish

2030-05-31

Last updated by the study team

2026-04-22

Who can join

Age: any. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Male participant at least in Tanner stage 3
• Previously cryopreserved and stored testicular tissue/cells (frozen due to an infertility-risking diagnosis or treatment such as chemotherapy or radiation) available for autologous transplantation and grafting
• Healthy enough to undergo anesthesia
• Written clearance for the procedure from the patient's hematologist or oncologist to confirm the patient has finished treatment for primary condition and are clear to undergo autologous stem cell transplant

You may not qualify if…

• Participants considered to be high risk for surgical complications
• Participants with a history of leukemia, lymphoma or testicular cancer or a cancer that likely involved testicles at the time of testicular tissue collection
• Diagnosed with psychological, psychiatric, or other conditions which prevent giving fully informed consent.

Where it is running

• Magee-Womens Hospital — Pittsburgh, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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