Short Term Corticosteroids in SARS-CoV2 Patients

Completed

Conditions studied: Corticosteroids, Covid19, SARS-CoV 2, Steroids, Dexamethasone

In brief

The investigators reviewed the charts of SARS-CoV-2 patients with pneumonia and moderate to severely elevated CRP and worsening hypoxemia who were treated with early, short-term dexamethasone.

Key facts

Study ID

NCT04445506

Run by

The Miriam Hospital

People needed

50

Starts

2020-04-01

Expected to finish

2020-05-31

Last updated by the study team

2020-06-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Moderate disease with at least a 30% increase in CRP within 36 hours of admission, and with increasing oxygen requirements.
• All patients with severe disease with evidence of escalating oxygen requirements
• The presence of secondary bacterial infections as a probable cause of increasing CRP levels was excluded in all selected patients.
• Pulmonary embolism and /or cardiac dysfunction were excluded as probable causes of worsening hypoxia in all selected patients.

You may not qualify if…

• All patients on other treatment modalities- Remdesivir and/or Convalescent plasma who showed evidence of clinical improvement as per decrease in CRP levels and/or oxygen requirements were excluded.
• Patient with associated COPD exacerbation who would benefit from the use of steroids.
• Patients with Diabetic ketoacidosis, hyperglycemic hyperosmolar state, active concurrent bacterial infections.
• Patients with history of steroid-induced mania and/or psychosis.

Where it is running

• The Miriam Hospital — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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