Assess the Risk of Cerebrovascular Disease

Recruiting now

Conditions studied: Cerebrovascular Disease

In brief

Intracranial artery stenosis is an important cause of ischemic stroke, but the degree of intracranial artery stenosis is not completely matched with the symptoms of ischemic stroke. Asymptomatic carotid stenosis (ACS) refers to does not appear related neurological symptoms of carotid stenosis and stroke or transient ischemic attack of carotid stenosis, did not happen cerebrovascular events such as stroke, but there have been a different degree of cognitive impairment, be badly in need of development of noninvasive imaging methods, objective evaluation of the ACS group cognitive impairment, and predict the ACS risk of ischemic stroke. Therefore, this topic proposed comprehensive cognitive assessment, CTA, double modal MRI techniques, clinical and biochemical indicator detection, mathematical modeling and statistical analysis techniques, assess the ACS group and normal person the cognitive ability, the difference of NVC and local perfusion, and follow-up ACS crowd of ischemic stroke and other cardiovascular events, discuss ACS and cognitive impairment, the correlation of NVC and local perfusion abnormalities, screening of radiographic predictor of ischemic stroke, and in the follow-up of ACS population in testing the sensitivity of the series of indicators and specific degrees.

Key facts

Study ID

NCT04443439

Run by

Tang-Du Hospital

People needed

100

Starts

2020-10-09

Expected to finish

2026-12-01

Last updated by the study team

2022-10-25

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Mild stenosis group: CTA suggested carotid stenosis < 30%;
• Moderate stenosis group: CTA suggested carotid stenosis of 30-69%;
• Severe stenosis group: CTA indicated carotid stenosis ≥70%;

You may not qualify if…

• dementia, MMSE score < 21;
• previous carotid stenosis related neurological symptoms or transient ischemic attack;
• other craniocerebral lesions, such as craniocerebral trauma, tumor, inflammation, and complications of great vessels (cerebral infarction or cerebral malacia);
• contraindications for MRI examination;
• recent use of psychoactive drugs or hormones.

Where it is running

• Wen Wang — Xi'an, China (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.