Mechanisms and Modulation of Pain Modulatory Capacity
Completed · Not applicable
Conditions studied: Musculoskeletal Pain
In brief
This project proposes to understand the sources of pain variability, and demonstrate that pain variability represents fluctuation in natural pain management. The project further proposes to determine if endogenous capacity to modulate pain can be trained to maximize their body's ability to manage pain, much as the way in which athletic performance can be trained.
Key facts
- Study ID
- NCT04441619
- Run by
- University of Florida
- People needed
- 128
- Starts
- 2020-11-30
- Expected to finish
- 2026-03-10
- Last updated by the study team
- 2026-06-30
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Asymptomatic people (ie no current pain conditions)
- Participants with widespread muscle pain (WMP) aged 18 years of age and older
- Participants with WMP must meet the ACR (2010) diagnostic criteria of multiple regions of muscle pain
- The asymptomatic group will be free of current wrist/hand, elbow, or shoulder pain and chronic pain conditions (eg irritable bowel syndrome, FM)
You may not qualify if…
- Participation in a conditioning program specific to the biceps in the past 6 months
- Any report of wrist/hand, elbow, or shoulder pain in the last 3 months
- Any chronic medical conditions that may affect pain perception (e.g., diabetes, high blood pressure), kidney dysfunction, muscle damage, or major psychiatric disorder
- Use of any intervention (including but not limited to medication, massage, and stretching) for symptoms induced by pain training for the duration of the study
- Positive result on pre-MRI metal screening or pregnancy test due to contraindication for the MRI environment.
- Any participant with ferromagnetic metal in the head, neck, or abdominal cavity
Where it is running
- Unversity of Florida — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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