Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Trial

Completed · Phase 2/Phase 3

Conditions studied: Arthritis Knee, Arthritis of Hip

In brief

Clinicians commonly utilize intraarticular injections to treat symptomatic primary arthritis. Steroid injections are common yet have immune-modulating effects and can alter gene expression which may delay definitive arthroplasty and further damage cartilage. Non-steroidal anti-inflammatory (NSAID) injections may offer a safer profile due to their differing mechanism of action; however, there is a relative dearth of information regarding their efficacy. This non-inferiority study compares the effectiveness of triamcinolone versus ketorolac in treating symptoms of moderate to advanced primary osteoarthritis of the hip and knee.

Key facts

Study ID

NCT04441112

Run by

Saint Alphonsus Regional Medical Center

People needed

120

Starts

2018-05-20

Expected to finish

2019-08-20

Last updated by the study team

2020-06-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Symptomatic, radiographically proven degenerative joint disease in the hip or knee

You may not qualify if…

• recent injection in the hip or knee within the previous 3 months
• history of traumatic osteoarthritis or ligamentous reconstruction
• chronic narcotic use
• history of inflammatory or neuropathic arthropathy
• pregnant and/or nursing women
• allergy or strong reaction to study medications

Where it is running

• Saint Alphonsus Regional Medical Center — Boise, Idaho, United States

Full record on ClinicalTrials.gov

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