Barts-MINOCA Registry

Recruiting now

Conditions studied: Myocardial Infarction, Gender, Coronary Microvascular Disease

In brief

The last 15 years the introduction of primary angioplasty has radically improved outcomes for acute myocardial infarction (AMI). However, the system wide availability of prompt investigation has revealed an important group of patients where progress has stalled, the diagnosis is unclear and therapeutic approaches are uncertain. Myocardial infarction with non-obstructive coronary arteries (MINOCA) is found in 1 - 13% of all patients with a clinical diagnosis of AMI. These patients present a therapeutic predicament since coronary revascularization is not appropriate. Guidelines do not exist for their management - yet the condition is not benign - the 12-month prognosis, although better than obstructive coronary artery disease patients is still guarded with recent data suggesting many questions remain unanswered.

Key facts

Study ID

NCT04440761

Run by

Queen Mary University of London

People needed

3000

Starts

2020-07-01

Expected to finish

2026-09-16

Last updated by the study team

2025-11-18

Who can join

Age: 16 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Both male and female patients ≥16 years of age will be included
• All patients will have a diagnosis MINOCA. Any patient who does not have a clear cause of troponin rise

You may not qualify if…

• Patients <16 years will not be included in this study.

Where it is running

• Barts Health NHS Trust — London, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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