fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Recruiting now
Conditions studied: Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury, Surgical Wound, Cornea Injury, Cornea, Keratoconus
In brief
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
Key facts
- Study ID
- NCT04439552
- Run by
- Boston Children's Hospital
- People needed
- 60
- Starts
- 2021-10-04
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2025-12-19
Who can join
Age: 8 and older, up to 35. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- CXL Group
- Age 8-35 years
- Clinical diagnosis of keratoconus and seeking CXL treatment
- English speaking ability sufficient to comprehend consent with parental assistance
- MRI compatible
- Ability to lie still for an MRI session (60 minutes)
- Control Group
- Age 8-35 years
- No diagnosis of keratoconus
- English speaking ability sufficient to comprehend consent with parental assistance
- MRI compatible
- Ability to lie still for an MRI session (60 minutes)
- Exclusion Criteria (Both Groups):
- Claustrophobic
- Weight > 285 lbs (weight limit of the MRI table)
- Significant medical history, including:
- Current DSM-IV-TR axis I psychiatric disorders. Chronic pain Significant head injury Seizures Brain tumor Cerebrovascular accident Neurological disease aside from migraine HIV-AIDs Prescription medication strongly implicated in causing dry eyes
- Magnetic implants or metal-containing tattoos on their chest or above
- Pregnancy
- History of contact lens wear
- Any allergic response to a numbing eyedrop in the past
Where it is running
- Boston Children's Hospital — Boston, Massachusetts, United States (enrolling)
Full record on ClinicalTrials.gov
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