Trial of Antimicrobial Restraint in Presumed Pneumonia

Completed · Not applicable

Conditions studied: Healthcare-Associated Pneumonia, Sepsis

In brief

The objective of this cluster-randomized crossover study is to determine the effect of delaying antimicrobial initiation until objective microbiologic data is obtained in patients with presumed ICU-acquired pneumonia without septic shock.

Key facts

Study ID

NCT04438187

Run by

University of Kansas Medical Center

People needed

186

Starts

2021-02-01

Expected to finish

2022-06-30

Last updated by the study team

2024-08-19

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Intubated patients admitted to a surgical or trauma intensive care unit that have had an appropriate quantitative or semi-quantitative endobronchial sputum culture sent ≥48 hours into their ICU admission
• Primary pathology managed by surgical specialty
• Age ≥18 years.

You may not qualify if…

• Non-intubated patients.
• Intubated patients with concern for active infection that is not suspected to be pneumonia (i.e. intra-abdominal infection, skin and soft tissue infection, urinary tract infection, etc.)
• Primary disease not surgical or traumatic in nature
• Primary diagnosis of burns
• Incarcerated status
• Pregnant status or delivery during this hospitalization.
• On active immunosuppressive medications (or taking as a home medication prior to arrival)

Where it is running

• KU Medical Center — Kansas City, Kansas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.