Nedaplatin Versus Cisplatin in Treatment for Nasopharyngeal Carcinoma

Recruiting now · Phase 3

Conditions studied: Nasopharyngeal Carcinoma

In brief

To compare the effectiveness and toxicity of nedaplatin versus cisplatin in induction chemotherapy combined with concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma.

Key facts

Study ID

NCT04437329

Run by

Affiliated Cancer Hospital & Institute of Guangzhou Medical University

People needed

352

Starts

2020-08-01

Expected to finish

2029-06-30

Last updated by the study team

2022-05-10

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with newly histologically confirmed non-keratinizing nasopharyngeal carcinoma, including WHO II or III
• Original clinical staged as III-IVa (except T3-4N0) according to the 8th edition American Joint Committee on Cancer staging system
• No evidence of distant metastasis (M0)
• Age between 18-65
• WBC≥4×10\^9/ l, platelet ≥ 100×10\^9/ l and hemoglobin ≥ 90g/l
• With normal liver function test (TBIL、ALT、AST ≤ 2.5×uln)
• With normal renal function test (creatinine ≤ 1.5×uln or ccr ≥ 60ml/min)
• Satisfactory performance status: KARNOFSKY scale (KPS) > 70
• Patients must give signed informed consent

You may not qualify if…

• Histologically confirmed keratinizing nasopharyngeal carcinoma (WHO I)
• Age >65 or < 18 years
• Treatment with palliative intent
• Prior malignancy except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer
• History of previous radiotherapy, chemotherapy, or surgery (except diagnostic) to the primary tumor or nodes
• History of previous radiotherapy
• Pregnancy or lactation
• Any severe intercurrent disease, which may bring unacceptable risk or affect the compliance of the trial, for example, unstable cardiac disease requiring treatment, acute exacerbation of chronic obstructive pulmonary disease or other respiratory illness requiring admission to hospital, active hepatitis, and mental disturbance

Where it is running

• Department of radiotherapy(Section 5),Affiliated Cancer Hospital & Institute of Guangzhou Medical University — Guangzhou, Guangdong, China (enrolling)

Full record on ClinicalTrials.gov

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