Renal Metabolism of Glycolate to Oxalate

Running, not enrolling · Not applicable

Conditions studied: Healthy

In brief

This study will determine the contribution of glycolate metabolism to urinary oxalate excretion in healthy subjects, using carbon 13 isotope glycolate tracer technique and a low-oxalate controlled diet.

Key facts

Study ID

NCT04437225

Run by

University of Alabama at Birmingham

People needed

15

Starts

2020-03-12

Expected to finish

2027-09-01

Last updated by the study team

2026-05-29

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Mentally competent adults, able to read and comprehend the consent form
• 18-75 years of age
• Body Mass Index (BMI) between 19 and 40
• In good health as judged from a medical history, reported medications, and a complete blood metabolic profile
• Acceptable 24 hour urine collections (performed twice for screening)

You may not qualify if…

• History of any hepatic, renal, bowel, or endocrine disease or any other condition that may influence the absorption, transport or urine excretion of ions
• Abnormal urine chemistries or blood metabolic profiles
• Poor 24 hour urine collections completed during screening, judged by 24 hour urine creatinine excretion (indicative of not collecting all urine in the 24 hour period)
• Pregnancy, intention to become pregnant in the near future, or lactation
• Aged <18 or >75
• BMI <19 or >40

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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