Antibiotic Dosing in Geriatric Patients At the Emergency Department

Recruiting now

Conditions studied: Elderly Infection, Frailty, Frail Elderly Syndrome, Infection, Bacterial

In brief

In this pilot study, we will investigate whether - with the current dosing regimens, used in the Ghent University Hospital - pharmacodynamic targets regarding beta-lactam antibiotics (more specific Amoxicilline-Clavulanate, Piperacillin-Tazobactam and Temocillin) are attained in frail patients admitted to the geriatric department.

Key facts

Study ID

NCT04436991

Run by

University Hospital, Ghent

People needed

180

Starts

2018-01-03

Expected to finish

2025-01-01

Last updated by the study team

2024-09-19

Who can join

Age: 75 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients presenting at the emergency department and later on admitted to the geriatric department
• Patient age 75 years or older
• Patients with geriatric profile according to KATZ scale, G8 screening test or CIRS score.
• Patient receiving antibiotic treatment (amoxicillin-clavulanate, piperacillin-tazobactam)
• Intravenous access available for blood sampling. For measurement of the peak concentration an intravenous access other than the drug infusion line is required.

You may not qualify if…

• Admission to other units than the geriatric department incl. the ICU.
• Absence of informed consent
• Known hypersensitivity to beta-lactam antibiotics
• Patients who received oral amoxicillin-clavulanate prior to admission will not be included in the iv. amoxicillin-clavulanate group.

Where it is running

• University Hospital Ghent — Ghent, Belgium (enrolling)

Full record on ClinicalTrials.gov

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