Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40%

Completed · Phase 3 · Has a placebo group

Conditions studied: Heart Failure

In brief

The purpose of this study is to evaluate the effect of finerenone compared to placebo (a tablet without active substance) in the reduction of cardiovascular death (generally meaning death due to disease of the heart or blood vessels) and total Heart Failure (HF) events, including HF hospitalization and urgent visits for HF(generally meaning a hospital stay or urgent presentation to a healthcare unit due to worsening symptoms of heart failure) in patients suffering from HF with an ejection fraction greater than or equal to 40%. Researchers will also collect information on how much the heart disease has impact on patient's lives, change of kidney function, and how well finerenone treatment is tolerated. The study plans to enroll 6000 male and female patients of the age of 40 years and above suffering from heart failure with ejection fraction greater than or equal to 40%. Participants will take the study product as oral tablet with a dose between 0 (Placebo) 40 mg once daily. Study duration will be up to 43 months.

Key facts

Study ID: NCT04435626
Run by: Bayer
People needed: 6016
Starts: 2020-09-14
Expected to finish: 2024-06-14
Last updated by the study team: 2025-08-26

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Participant (male or female) must be aged 40 years and older.
Diagnosis of heart failure with New York Heart Association(NYHA) class II-IV, ambulatory or hospitalized primarily for heart failure.
On diuretic treatment for at least 30 days prior to randomization.
Documented left ventricular ejection fraction (LVEF) of ≥40% measured by any modality within the last 12 months.
Structural heart abnormalities based on any local imaging measurement within the last 12 months, defined by at least one of the following findings: left atrial diameter (LAD) ≥3.8cm, left atrial area (LAA) ≥20cm2, left atrial volume index (LAVI) >30 mL/m2, left ventricular mass index (LVMI) ≥115 g/m2 (♂)/ 95 g/m2 (♀), septal thickness or posterior wall thickness ≥1.1 cm
n-terminal prohormone B-type natriuretic peptide (NT-proBNP) ≥300 pg/mL (BNP ≥100 pg/mL) in sinus rhythm and patient does not have an ongoing diagnosis of paroxysmal atrial fibrillation or NT-proBNP ≥900 pg/mL (BNP ≥300 pg/mL) in atrial fibrillation (or if atrial fibrillation status is unknown or if patient has an ongoing diagnosis of paroxysmal atrial fibrillation) for participants obtained at the following time:
Within 90 days prior to randomization if patient had been hospitalized for heart failure (HF) requiring initiation or change in HF therapy or if patient had an urgent visit for HF requiring intravenous (IV) diuretic therapy, both within 90 days prior to randomization OR
Within 30 days prior to randomization if patient has not been hospitalized for HF nor had an urgent HF visit within the past 90 days.
Women of childbearing potential can only be included in the study if a pregnancy test is negative at screening and baseline and if they agree to use adequate contraception which is consistent with local regulations regarding the methods for contraception for those participating in clinical trials.

You may not qualify if…

Estimated glomerular filtration rate (eGFR) <25 mL/min/1.73 m² at either screening or randomization visit.
Serum/plasma potassium >5.0 mmol/L at either screening or randomization visit.
Acute inflammatory heart disease, e.g. acute myocarditis, within 90 days prior to randomization
Myocardial infarction or any event which could have reduced the ejection fraction within 90 days prior to randomization
Coronary artery bypass graft surgery in the 90 days prior to randomization
Percutaneous coronary intervention in the 30 days prior to randomization
Stroke or transient ischemic cerebral attack within 90 days prior to randomization
Probable alternative cause of participants' HF symptoms that in the opinion of the investigator primarily accounts for patient's dyspnea such as significant pulmonary disease, anemia or obesity. Specifically, patients with the below are excluded: Severe pulmonary disease requiring home oxygen, or chronic oral steroid therapy, History of primary pulmonary arterial hypertension, Hemoglobin <10 g/dl, Valvular heart disease considered by the investigator to be clinically significant, Body Mass Index (BMI) >50 kg/m2 at screening
Systolic blood pressure(SBP) ≥160 mmHg if not on treatment with ≥3 blood pressure lowering medications or ≥180 mmHg irrespective of treatments, on 2 consecutive measurements at least 2-minute apart, at screening or at randomization.
Concomitant systemic therapy with potent cytochrome P450 isoenzyme 3A4 (CYP3A4) inhibitors (e.g. itraconazole, ritonavir, indinavir, cobicistat, clarithromycin) or moderate or potent CYP3A4 inducers, that cannot be discontinued 7 days prior to randomization and for the duration of the treatment period.

Where it is running

Eastern Shore Research Institute, LLC | Fairhope, AL — Fairhope, Alabama, United States
Mobile Heart Specialists - Providence — Mobile, Alabama, United States
University of Arizona Clinical and Translational Sciences Research Center — Tucson, Arizona, United States
Heart Clinic Arkansas — Little Rock, Arkansas, United States
WestSide Medical — Beverly Hills, California, United States
CA Heart and Vein Specialists — Huntington Beach, California, United States
UCI Medical Center - Neurology — Orange, California, United States
Sutter Medical Center - Cardiology — Sacramento, California, United States
NorthBay Clinical Research, LLC | Santa Rosa, CA — Santa Rosa, California, United States
The Lundquist Institute - Gynecology — Torrance, California, United States
Blue Coast Research Center, LLC — Vista, California, United States
Interventional Cardio Medical- DCT Department — West Hills, California, United States
Interventional Cardiology Medical Group | West Hills, CA — West Hills, California, United States
VA Eastern Colorado Health Care System — Aurora, Colorado, United States
Colorado Springs Cardiology - Woodmen Medical Plaza — Colorado Springs, Colorado, United States
South Denver Cardiology Associates, PC — Littleton, Colorado, United States
Cardiovascular & Vein Center of Florida | Bradenton, FL — Bradenton, Florida, United States
Nova Clinical Research - Blake Medical Center — Bradenton, Florida, United States
Cardiology Associates Research Company — Daytona Beach, Florida, United States
North Florida Foundation for Research and Education - Clinical Trial Center — Gainesville, Florida, United States
LifeSpring Research Foundation, LLC — Miami, Florida, United States
Southwest Florida Research | Naples, FL — Naples, Florida, United States
East Coast Institute for Research | St. Augustine, FL — Saint Augustine, Florida, United States
Cardiology Partners Clinical Research Institute | Wellington Office — Wellington, Florida, United States
Cardiology, PC — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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