A Phase 3 Safety and Efficacy Study of Intravitreal Administration of Zimura (Complement C5 Inhibitor)

Completed · Phase 3 · Has a placebo group

Conditions studied: Geographic Atrophy, Macular Degeneration

In brief

The objectives of this study was to evaluate the safety and efficacy of avacincaptad pegol intravitreal administration in participants with geographic atrophy secondary to age-related macular degeneration (AMD)

Key facts

Study ID

NCT04435366

Run by

IVERIC bio, Inc.

People needed

448

Starts

2020-06-22

Expected to finish

2023-08-22

Last updated by the study team

2025-10-21

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects of either gender aged ≥ 50 years
• Diagnosis of Non-foveal GA secondary to dry AMD

You may not qualify if…

• Any prior treatment for AMD (dry or wet) or any prior intravitreal treatment for any indication in either eye, except oral supplements of vitamins and minerals
• Any intraocular surgery or thermal laser within 3 months of trial entry.
• Any prior thermal laser in the macular region, regardless of indication
• Any ocular or periocular infection (including blepharitis), or ocular surface inflammation in the past 12 weeks.
• Previous therapeutic radiation in the region of the study eye
• Any sign of diabetic retinopathy in either eye

Where it is running

• Retinal Diagnostic Center — Campbell, California, United States
• Eye Medical Center of Fresno — Fresno, California, United States
• Retina Consultants of Orange County — Fullerton, California, United States
• University of California, San Diego — La Jolla, California, United States
• Jules Stein Eye Institute/David Geffen School of Medicine — Los Angeles, California, United States
• Northern California Retina Vitreous Associates — Mountain View, California, United States
• California Retina Consultants — Oxnard, California, United States
• Southern California Desert Retina Consultants — Palm Desert, California, United States
• Doheny Eye Center, UCLA — Pasadena, California, United States
• Retina Consultants of Southern California — Redlands, California, United States
• Retinal Consultants Medical Group, Inc. — Sacramento, California, United States
• Orange County Retinal Medical Group — Santa Ana, California, United States
• University of Colorado — Aurora, Colorado, United States
• Retina Consultants of Southern Colorado, P.C. — Colorado Springs, Colorado, United States
• Colorado Retina Associates — Lakewood, Colorado, United States
• Connecticut Eye Consultants, P.C. — Danbury, Connecticut, United States
• Retina Group of New England, PC — Waterford, Connecticut, United States
• Florida Eye Clinic — Altamonte Springs, Florida, United States
• Rand Eye Institute — Deerfield Beach, Florida, United States
• Retina Group of Florida — Fort Lauderdale, Florida, United States
• Retina Health Center — Fort Myers, Florida, United States
• National Ophthalmic Research Institute — Fort Myers, Florida, United States
• VitreoRetinal Associates, P.A. — Gainesville, Florida, United States
• Florida Eye Associates — Melbourne, Florida, United States
• Retina-Vitreous Associates Medical Group — Beverly Hills, California, United States

Full record on ClinicalTrials.gov

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