Using Combined EEG and Non-invasive Brain Stimulation to Examine and Improve Reward Functioning in Opioid Use Disorder
Completed · Not applicable · Has a placebo group
Conditions studied: Opioid-use Disorder
In brief
The primary aims of this study are to identify impaired cognitive control in opioid use disorder (OUD) and subsequently to examine the effects of transcranial magnetic stimulation (TMS) on reward processing, as measured by the reward positivity (an electrophysiological signal) in people with OUD. To this end, the investigators will adopt a randomized sham-controlled trial to evaluate the efficacy of Ri-TMS on cognitive control in OUD. The investigators hypothesize that Ri-TMS will be successful in modulating the reward positivity in opioid users in the active TMS condition.
Key facts
- Study ID
- NCT04432493
- Run by
- Rutgers University
- People needed
- 81
- Starts
- 2020-02-20
- Expected to finish
- 2022-08-31
- Last updated by the study team
- 2024-03-08
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Native English speakers
- Males and Females aged 18-55 years old
- Ability to provide informed written or verbal consent
- Opioid dependent individuals (according to the Alcohol, Smoking and Substance Involvement Screening Test opioid dependence score), or
- Healthy controls with no history of significant substance use
You may not qualify if…
- Un-correctable visual impairment
- Uninterruptable central nervous system medication
- TMS contraindications (e.g., pregnancy, braces, history of seizures, metal implants).
- History of neurological or psychiatric illness
- Diagnosed learning disability
- History of significant head injury (loss of consciousness for more than five minutes)
- Substance abuse (Participants who score above 39.5 on the Global Continuum of Substance Risk scale of the Alcohol, Smoking and Substance Involvement Screening Test - controls only)
- Use of psychoactive or vasoactive medications
Where it is running
- Rutgers University - Newark — Newark, New Jersey, United States
Full record on ClinicalTrials.gov
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