Heterozygous Individuals for AGXT and Kidney Stones

Enrolling by invitation · Not applicable

Conditions studied: Kidney Stone, Urolithiasis, Calcium Oxalate

In brief

This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production. Participants will consume a controlled low-oxalate diet and provide blood and urine samples to measure the amount of oxalate in their bodies.

Key facts

Study ID

NCT04430426

Run by

University of Alabama at Birmingham

People needed

4

Starts

2027-07-01

Expected to finish

2032-08-01

Last updated by the study team

2026-07-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• at least 18 years of age
• history of calcium oxalate stones
• heterozygous mutation of the AGXT gene, as evidenced by results from the Invitae Nephrolithiasis Panel
• willingness to comply with a controlled diet for five days

You may not qualify if…

• pregnant individuals
• individuals who are currently breast feeding

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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