Cryoablation for the Promotion of Local Tumor Infiltration in Patients With Mesothelioma

Withdrawn before enrolling · Not applicable

Conditions studied: Mesothelioma

In brief

This trial evaluates if cryoablation will stimulate a local immune response by cluster of differentiation 8 positive (CD8+) cells which are not present in ablation naive regions of the tumors in patients with mesothelioma. Cryoablation uses extreme cold to damage or destroy tumor lesions. Mesothelioma is a rare cancer that grows and spreads quickly, and has low survival rates. The information learned from this study may provide evidence as to whether there is a measurable, local immune response from cryoablation. Studying samples of mesothelioma tissue in the laboratory from patients who have undergone biopsy may help doctors learn more about the effects of cryoablation on cells. It may also help doctors understand how well patients respond to treatment.

Key facts

Study ID

NCT04429204

Run by

Jonsson Comprehensive Cancer Center

People needed

0

Starts

2021-12-01

Expected to finish

2023-12-01

Last updated by the study team

2021-06-14

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults that have been identified at tumor board with high suspicion for mesothelioma and are anticipated to be surgical candidates, as determined/discussed at Mesothelioma Tumor Board

You may not qualify if…

• Patients that have a questionable diagnosis of mesothelioma (i.e. there are other potentially more likely considerations in the differential diagnosis) or in patients that would not be expected to be good surgical candidates

Where it is running

• UCLA / Jonsson Comprehensive Cancer Center — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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