Evaluating Cascade Communication Methods
Completed
Conditions studied: BRCA1 Mutation, BRCA2 Mutation
In brief
Hereditary cancer programs face challenges with respect to effective communication of genetic test results within families and uptake of genetic testing by relatives. This study aims to determine if a "disclosure toolkit" provided to the index participant (carrier of cancer risk gene mutation) contributes to sharing genetic test results with relatives, if there are preferred disclosure methods, and whether toolkit use contributes towards at-risk relatives pursuing genetic testing.
Key facts
- Study ID
- NCT04428736
- Run by
- University of Pennsylvania
- People needed
- 52
- Starts
- 2020-02-19
- Expected to finish
- 2025-12-31
- Last updated by the study team
- 2026-04-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 18 years of age and older
- Proband must be carrier of a high risk cancer predisposition gene
- Relative must be established relative of respective proband participant and deemed "at-risk" for familial gene mutation and eligible genetic testing candidate as per study team determination
- Participants must be able to understand and read English
- Participants must be able to provide informed verbal or written consent
You may not qualify if…
- <18 years of age
- Individuals who are mutation negative for high risk cancer predisposition genes
- Individuals who are carriers of a variant of uncertain significance in any gene
- Individuals who test positive for more than 1 high risk cancer predisposition gene
- Individuals who cannot speak and read English
- Individuals who do not have any at-risk relatives (eligible for familial gene mutation testing) as per study team determination
- Major psychiatric illness or cognitive impairment that in the judgement of the study investigators or study staff would preclude study participation
- Any patients who are unable to comply with the study procedures as determined by the study investigators or study staff
- No available family members for cascade opportunity (adoption, estrangement, etc.)
Where it is running
- Abramson Cancer Center — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.