Neuromodulation and Cognitive Training for Substance Use Disorders

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Stimulant Use, Alcohol Use Disorder

In brief

The relapsing nature of substance use disorder is a major obstacle to successful treatment. About 70% of those entering treatment will relapse within one year. To improve treatment outcome, new interventions targeting the underlying brain biomarkers of relapse vulnerability hold significant promise in reducing this critical public health problem. This study is testing a new intervention, namely tDCS-Augmented Cognitive Training, to engage these brain biomarkers to improve cognition and improve treatment outcomes.

Key facts

Study ID: NCT04426214
Run by: University of Minnesota
People needed: 80
Starts: 2021-07-16
Expected to finish: 2026-09-01
Last updated by the study team: 2025-08-26

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Abstinent from any substance or alcohol use (excluding caffeine or nicotine) for a minimum of 3 weeks at study enrollment
Has the intention to remain in their treatment program(s) until the end of the intervention portion of the study.
Able to provide written consent and comply with study procedures.
Meets the MINI 7 diagnostic criteria for either stimulant use disorder (SUD) or alcohol use disorder (AUD).

You may not qualify if…

Any medical condition or treatment with neurological sequelae (i.e. stroke, tumor, HIV)
Over 9 months of abstinence from substance use
A head injury resulting in a loss of consciousness exceeding 30 minutes (i.e., moderate or severe TBI)
Presence of a condition that would render study measures difficult or impossible to administer or interpret
Age outside the range of 18 to 65
Primary current substance use disorder diagnosis (according to MINI 7 diagnostic criteria) for a substance other than stimulant or alcohol, except for caffeine or nicotine (Nicotine use will be recorded but is not exclusionary)
Entrance to the treatment program under a court mandate. (i.e. legally incarcerated)
History of ECT or cortical energy exposure within the past 6 months, including participation in any other neuromodulation studies

Where it is running

University of Minnesota Fairview — Minneapolis, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.