Effects of COVID-19 Convalescent Plasma (CCP) on Coronavirus-associated Complications in Hospitalized Patients
Completed · Phase 2 · Has a placebo group
Conditions studied: COVID-19, Sars-CoV2
In brief
The purpose of this study assess the efficacy and safety of anti-SARS-CoV-2 convalescent plasma in hospitalized patients with acute respiratory symptoms up to 14 days after the onset of initial symptoms.
Key facts
- Study ID
- NCT04421404
- Run by
- Priscilla Hsue, MD
- People needed
- 34
- Starts
- 2020-06-09
- Expected to finish
- 2021-04-30
- Last updated by the study team
- 2022-10-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Contraindication to transfusion due to inability to tolerate additional fluid, such as due to decompensated congestive heart failure
- Baseline requirement for oxygen supplementation prior to COVID-19 infection or use of positive pressure therapy for sleep disordered breathing
- Currently experiencing severe hypoxemic failure, as defined in study endpoints
- Prior receipt of plasma products, IVIG, or hyperimmune globulin within past 3 months
- Not currently enrolled another interventional clinical trial of COVID-19 treatment.
- Note: If taking medications with potential anti-COVID activity for the purpose of COVID-19 treatment that do not yet have data to support efficacy, such as IL-6 antagonists, these medications must be stopped prior to enrollment. Receipt of current standard of care COVID-19 treatment, including remdesivir and dexamethasone is permitted and should be recorded as a concomitant medication.
- Note: Pregnancy is not exclusionary but will merit additional discussion of risks \& benefits in the context of ongoing pregnancy
Where it is running
- San Francisco General Hospital — San Francisco, California, United States
- UCSF Medical Center at Mount Zion — San Francisco, California, United States
- University of California, San Francisco Medical Center (Parnassus Campus) — San Francisco, California, United States
Full record on ClinicalTrials.gov
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