Characterizing Subjective and Physiological Responses to Stress and Pain and Cognitive Learning and Executive Function

Completed

Conditions studied: Pain Response, Stress, Trauma

In brief

The study design is to assess the between groups factor (controls, chronic pain, addicted individuals) and repeated measures factor of pain/stress (pain vs no pain) along with a longitudinal component to assess stress, pain and addictive behaviors in daily life.

Key facts

Study ID

NCT04419831

Run by

Yale University

People needed

81

Starts

2022-04-14

Expected to finish

2023-12-30

Last updated by the study team

2024-02-07

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Between ages 18-50 years;
• Able to read and write English;
• 50 individuals meeting DSM V criteria for Binge Heavy drinkers, using NIAAA criteria for alcohol intake 50 individuals meeting DSM V criteria for Cannabis Use Disorder 50 individuals meeting DSM V criteria for Alcohol Use Disorder 50 Individuals with Moderate to Severe Pain 50 individuals meeting DSM V criteria for Opioid Use Disorder who are initiating treatment
• Physically healthy as determined by Physical Exam, EKG and blood analyses
• Body Mass Index (BMI) in the 18-30 range;

You may not qualify if…

• Any psychotic disorder or current psychiatric symptoms requiring specific attention, including active symptoms of psychosis or suicidal/homicidal ideation.
• Any Current Substance Use Disorder including alcohol, cannabis, cocaine, opioids, sedatives/hypnotics. For alcohol, cannabis, and opioid subjects, exclusion for the abused drug will not apply.
• Individuals taking any prescription medications or over-the counter medications regularly;
• Women with irregular menstrual cycles or who are nursing, dysmennorheic, amenorrheic, menopausal, or had premenstrual dysphoric disorder or those on birth control pills;
• Women who are pregnant as determined by the urine pregnancy test at each laboratory admission;
• Inability to give informed consent;
• Traumatic brain injury or loss of consciousness;
• Individuals with current or past history of seizure disorders

Where it is running

• Yale Stress Center — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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