ICG Fluorescence Imaging in Open Fracture Trauma Patients

Completed

Conditions studied: Trauma Injury

In brief

This is a prospective observational study that will evaluate the association between bone and tissue perfusion, as measured by indocyanine green (ICG) fluorescence imaging, and complications, in an effort to develop ICG fluorescence imaging as a diagnostic tool to quantitatively guide operative debridement.

Key facts

Study ID

NCT04416412

Run by

Dartmouth-Hitchcock Medical Center

People needed

124

Starts

2020-10-01

Expected to finish

2026-07-01

Last updated by the study team

2026-07-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients 18 years of age or older.
• Open extremity fracture.
• Planned definitive fracture management with external fixation, internal fixation, or joint fusion.
• Open fracture wound management that includes formal surgical debridement within 72 hours of their injury.
• Will have all planned fracture care surgeries performed by a participating surgeon or delegate.
• Provision of informed consent.

You may not qualify if…

• Inability of patient to provide informed consent
• Fracture of the hand.
• Iodine allergy.
• Received previous surgical debridement or management of their fracture at a non-participating hospital or clinic.
• Open fracture managed outside of the participating orthopaedic service.
• Chronic or acute infection at or near the fracture site at the time of initial fracture surgery.
• Burns at the fracture site.

Where it is running

• University of California, Irvine — Irvine, California, United States
• University of Maryland, Baltimore R. Cowley Shock Trauma — Baltimore, Maryland, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Dartmouth Hitchcock Medical Center — Lebanon, New Hampshire, United States

Full record on ClinicalTrials.gov

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