Highly Suppressive Treg in Delayed and Slow Graft Function After Kidney Transplantation
Running, not enrolling
Conditions studied: DGF, Kidney Transplant; Complications
In brief
Delayed/slow graft function is the most common complication after kidney transplantation with an incidence over 20% and is the result of ischemia-reperfusion injury. The increased use of marginal kidney grafts to palliate the organ shortage is leading to a continued rise in the incidence of delayed/slow graft function. Delayed/slow graft function, however, is associated with an increased risk of acute rejection and graft failure. There are currently no clinically accepted biomarkers and no specific treatments for delayed/slow graft function. Regulatory T cells are protective in ischemia-reperfusion injury and rejection by suppressing pathologic immune responses. We hypothesize that the pre-transplant measurement of highly suppressive regulatory T cell is an accurate biomarker for delayed/slow graft function and its immunologic consequences. Ultimately, marginal kidney graft allocation could be directed to regulatory T cell-robust recipients and regulatory T cell-directed therapies could decrease marginal kidney graft discards without increasing delayed/slow graft function or impacting outcomes.
Key facts
- Study ID
- NCT04414111
- Run by
- St. Louis University
- People needed
- 180
- Starts
- 2020-12-07
- Expected to finish
- 2027-07-31
- Last updated by the study team
- 2025-12-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult kidney transplant candidates immediately prior to their kidney transplant surgery
You may not qualify if…
- < 18 years old
- Active immunosuppressive drug use
- Hepatitis C
- HIV
Where it is running
- Loma Linda University Health Transplantation Institute — San Bernardino, California, United States
- Saint Louis University — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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