Inflammatory faCtors AfteR acUte Ischemic Stroke
Recruiting now · Not applicable
Conditions studied: Ischemic Stroke
In brief
ICARUS is an interventional single-centre hospital-based cohort study in patients admitted to the stroke unit with an acute ischemic stroke. The aims of the study are to i) define the characteristics and determinants of microglial activation after human stroke, and ii) assess the correlation of microglial activation with circulating inflammatory markers, structural brain changes on neuroimaging, and neurological outcomes. ICARUS involves serial TSPO-PET imaging along with serial MRI, immune cell profiling in blood, and both clinical and laboratory assessments in 36 patients with acute ischemic stroke caused by a cortical (N=18) or strictly subcortical (N=18) infarct. In a substudy, the investigators will include 10 independently recruited patients with acute ischemic stroke to assess MRI arterial spin labelling (ASL) sequences as a marker for perfusion measurement of the TSPO tracer.
Key facts
- Study ID
- NCT04412187
- Run by
- Martin Dichgans
- People needed
- 36
- Starts
- 2020-07-01
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2025-04-04
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 50 years
- Acute ischemic stroke (time frame: <72 hours) as defined by an acute focal neurological deficit in combination with a corresponding infarct as documented by a diffusion weighted imaging (DWI)-positive lesion on magnetic resonance imaging (MRI); presence of an infarct involving the cortex or a strictly subcortical infarct
- Written informed consent prior to study participation
- Willingness to participate in study assessments including follow-up
You may not qualify if…
- Unwillingness or inability to give written consent
- Prior history of stroke, multiple infarcts, infratentorial infarcts affecting the brain stem or cerebellum
- Known diseases of the CNS other than stroke
- Immunomodulatory therapies within the last 3 months prior stroke
- Chronic inflammatory disease
- Infectious diseases within the last 7 days prior stroke
- Conditions interfering with follow-up such as end-stage malignancy
- Contraindications for MRI or PET (pacemaker, aneurysm clip, cochlear implant etc.)
- Radiation exposure of > 10mSv per year
- Pregnant or breastfeeding women
- Participation in a clinical trial
Where it is running
- Insitute for Stroke and Dementia Research — Munich, Germany, Germany (enrolling)
- Department of Nuclear Medicine — Munich, Germany (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.