The Efficacy of Adjuvant Chemotherapy in Locally Advanced Cervical Cancer

Recruiting now · Not applicable

Conditions studied: Cervical Cancer

In brief

The aim of this trial was to evaluate the efficacy of adjuvant chemotherapy in the locally advanced cervical cancer with residual lesions after concurrent chemoradiation therapy.

Key facts

Study ID

NCT04409860

Run by

Chongqing University Cancer Hospital

People needed

120

Starts

2020-05-26

Expected to finish

2029-04-01

Last updated by the study team

2023-04-11

Who can join

Age: 18 and older, up to 75. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Cervical cancer stage IIb to IVa with histopathology of squamous cell carcinoma, adenosquamous cell carcinoma, adenocarcinoma
• Complete CCRT(Radiation Does: A point 85Gy(+/-10%)，B点50Gy(+/-10%)，concurrent platinum-containing chemotherapy (cisplatin or carboplatin))
• MRI is performed within 4 weeks after CCRT and shows residual lesions (non-lymph node≥10mm, lymph node shortest diameter≥15mm).
• ECOG<2
• Expected survival is longer than six months
• Hb≥70g/L、WBC≥3.5×109/ L 、ANC≥1.5×109/L、PLT≥80×109/L
• ALT and AST≤2×ULN, Serum creatinine≤1.5×ULN
• The serum or urine pregnancy test must be negative within 7 days before enrollment for the women of childbearing age who should agree that contraception must be used during the trial

You may not qualify if…

• Activity or uncontrol severe infection
• Liver cirrhosis, Decompensated liver disease
• History of immune deficiency, including HIV positive or suffering from congenital immunodeficiency disease
• Patients who cannot tolerate chemotherapy because of chronic renal insufficiency or renal failure
• Have suffered or combined with other malignant tumor
• Myocardial infarction, severe arrhythmia and NYHA (New York heart association)≥2 for congestive heart failure
• A history targeted therapy or pelvic artery embolization
• Artery-enous thrombosis within 6 months
• Patients with autoimmune diseases
• Complications, need to be treatment with drugs which may lead to liver or kidney injury
• Patients with disease progression after chemoradiation

Where it is running

• Chongqing Cancer Hospital — Chongqing, Chongqing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.